0091 The Association Between Sleep Health Facets and Inflammatory Markers: Results from the Einstein Aging Study

Abstract Introduction Prior research assessing self-reported or nocturnal sleep suggested that specific traits (sleep restriction in the laboratory; poor quality, disorders) are associated with both pro and anti-inflammatory cytokine C-Reactive Protein (CRP) levels. To extend prior research, we investigated associations between multiple dimensions of objectively assessed health circulating stimulated inflammatory markers a diverse sample older adults. Methods Participants Einstein Aging Study (EAS) were included (N=218, Mage=77.5 years, 6% female; 46% White, 38% Black, 14% Hispanic/other). A confirmatory factor analysis using wrist actigraphy variables over 16 days yielded 6-component multi-dimensional facets: Regularity, Alertness/Sleepiness (daytime), Timing, Efficiency, Duration, Rhythmicity. Inflammatory collected morning CRP reflecting current systemic inflammation, lipopolysaccharide (LPS)-stimulated levels (IL-1β, IL-4, IL-6, IL-8, IL-10, TNF